Abstract： Objective： To observe the clinical effect of Erxian tang combined with tamoxifen citrate tablets on breast cystic hyperplasia. Methods： A total of 82 patients with breast cystic hyperplasia were divided into the treatment group and the control group according to the random number table method，with 41 cases in each group. The control group was treated with tamoxifen citrate tablets， and the treatment group was additionally treated with Erxian tang based on the treatment of the control group. Both groups were treated for three menstrual cycles. The clinical effects and incidences of adverse reactions were compared between the two groups. Before and after treatment，the changes of scores of local symptoms and levels of serum endocrine hormones， including estradiol(E2)， progesterone(P) and prolactin(PRL)， in the two groups were observed. The recurrence rates were compared between the two groups. Results： After treatment，the scores of breast pain，nipple discharge，size of cysts and number of cysts in the two groups were decreased when compared with those before treatment， differences being significant(P＜ 0.05)； after treatment， the above scores in the treatment group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of serum PRL and E2 in the two groups were decreased when compared with those before treatment， and the levels of serum P were increased，differences being significant(P＜0.05)；after treatment，the levels of serum PRL and E2 in the treatment group were lower than those in the control group， and the level of serum P was higher， differences being significant(P＜0.05). The total clinical effective rate was 92.7% in the treatment group， and was 75.6% in the control group， the difference being significant(P＜0.05). The recurrence rate was 7.9% in the treatment group， and was 25.8% in the control group， the difference being significant(P＜ 0.05). The incidence of adverse reactions was 5.3% in the treatment group，and was 25.8% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Erxian tang combined with tamoxifen citrate tablets has a good curative effect on breast cystic hyperplasia， which can regulate the disorder states of endocrine hormones， alleviate the local symptoms of patients， and reduce the recurrence rates，with high administration safety.