Abstract：Objective：To observe the effects of modified Chuanqianghuo tang combined with tuina with manipulation and physiotherapy on shoulder joint function and scapulohumeral periarthritis in patients with shoulder pain. Methods： A total of 128 cases of patients with shoulder joint pain were divided into two groups by envelope method，with 64 cases in each group. The control group was treated with tuina with manipulation and physiotherapy， and the observation group was additionally treated with modified Chuanqianghuo tang based on the treatment of the control group. Curative effects， active range of joint motion，pain status，shoulder joint function and levels of inflammatory factor were compared between the two groups. Results： The total effective rate was 95.31% in the observation group， higher than that of 82.81% in the control group(P＜0.05). After treatment，active range of joint motion in the two groups was increased when compared with that before treatment(P＜0.05)；each score of shoulder joint function and levels of serum interleukin- 10(IL- 10) were increased(P＜0.05)； scores of Visual Analogue Scale(VAS) of pain，Pain Rating Index(PRI)，and Present Pain Intensity(PPI)，as well as levels of prostaglandin E2(PGE2) and tumor necrosis factor- α(TNF- α) in serum，and substance P(SP) in plasma were decreased(P＜0.05). After treatment， active range of joint motion in the observation group was larger than that in the control group(P＜0.05)， each score of shoulder joint function and serum IL- 10 level higher(P＜0.05)， scores of VAS，PRI，and PPI，as well as levels of PGE2 and TNF-α in serum，and SP lower(P＜0.05). Conclusion： Modified Chuanqianghuo tang combined with tuina with manipulation and physiotherapy has a good effect in the treatment of shoulder joint pain，and can relieve scapulohumeral periarthritis and recover shoulder joint function. Its mechanism maybe related to its positive regulation of inflammatory factor levels.