Objective： To observe the effect of the therapy of Haoqin Huaban tang combined with tripterygium glycosides on immune function of patients with eczematous dermatitis. Methods： A total of 168 patients with eczematous dermatitis were selected as research objects，and divided into the treatment group and the control group according to the random number table method，with 84 cases in each group. The control group was treated with tripterygium glycosides， and the treatment group was treated with Haoqin Huaban tang combined with tripterygium glycosides. The clinical effects in the two groups were compared，and the changes of levels of interleukin-4(IL-4)，interleukin-10(IL-10)，interferon-γ(IFN-γ)， T cell subsets(TH1， TH2， TH1/TH2)， skin barrier function and Chinese medicine syndrome scores were compared between the two groups before and after treatment. Results： After treatment， the levels of IL-4，IL-10 and IFN-γ in both groups were decreased when compared with those before treatment，and the levels of IL- 4，IL- 10 and IFN- γ in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment，the levels of TH1 and TH2 were decreased，and the levels of TH1/TH2 were increased，differences being significant(P＜0.05)；the levels of TH1 and TH2 in the treatment group were lower than those in the control group， and the level of TH1/TH2 was higher， differences being significant(P＜0.05). After treatment， the levels of epidermal water loss in both groups were decreased when compared with those before treatment，and the contents of cuticle water and cortex were increased，differences being significant(P＜0.05)；the level of epidermal water loss in the treatment group was lower than that in the control group，and the contents of cuticle water and cortex were higher， differences being significant(P＜0.05). After treatment， the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment，and the Chinese medicine syndrome score in the treatment group was lower than that in the control group， differences being significant(P＜ 0.05). The total effective rate of clinical effect was 97.62% in the treatment group and 89.29% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Haoqin Huaban tang combined with tripterygium glycosides has a good therapeutic effect on the treatment of eczematous dermatitis，which can relieve clinical symptoms，improve the levels of inflammatory factors and immune function，and enhance the skin barrier function of patients.