Abstract： Objective： To observe the effect of general anesthesia with acupuncture and medicine on hip arthroplasty in senile patients. Methods：A total of 100 cases of senile patients who was about to take hip arthroplasty were selected as the study objects and divided into the control group and the study group according to the random number table method，with 50 cases in each group. The control group was given general anesthesia with simple medicine， and the study group was given general anesthesia with acupuncture and medicine. Scores of Visual Analogue Scale(VAS) at different time points before and after surgery，and levels of mean arterial pressure(MAP) and heart rate(HR) at different time points after surgery were compared between the two groups. The dosage of propofol and remifentanil during surgery and the incidence of postoperative adverse reactions after surgery were compared between the two groups. Results： There was no significant difference being found in the comparison of MAP levels five minutes before catheter withdrawal， during withdrawal， and after awakening between the two groups(P＞0.05)， and HR levels five minutes before catheter withdrawal， during withdrawal， and after awakening in the study group were lower than those in the control group(P＜0.05). The dosage of propofol and remifentanil during surgery and the incidence of postoperative adverse reactions after surgery in the study group were lower than those in the control group(P＜0.05). The VAS scores in the study group at the 6th hour， 12th hour and 24th hour after surgery were lower than those in the control group(P＜0.05). Conclusion： The application of general anesthesia with acupuncture and medicine to hip arthroplasty in senile patients can effectively relieve postoperative pain and reduce intraoperative local anesthetic dose， with few adverse reactions.