Abstract：Objective：To observe the curative effect of Chinese medicine hot compress，needle knife and tuina for scapulohumeral periarthritis with cold congealing in the sinews syndrome. Methods：A total of 136 cases of senile patients with scapulohumeral periarthritis were selected and divided into the control group and the observation group according to the random number table method， with 68 cases in each group. The control group was given oral administration of celecoxib capsules combined with rehabilitation exercise，and the observation group was additionally treated with Chinese medicine hot compress，needle knife and tuina based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects in the two groups were compared. Before treatment， and after two and four weeks of treatment，the changes in Visual Analogue Scale(VAS) for pain and World Health Organization Quality of Life (WHOQOL- BREF) in the two groups were compared. Before treatment， and after four weeks of treatment， the changes in Constant- Murley Score(CMS) of shoulder function， hemorheology indexes， and levels of inflammatory factors in serum including tumor necrosis factor- α(TNF-α)，cyclooxygenase-2 (COX- 2) and interleukin- 1β(IL- 1β) in peripheral blood in the two groups were compared. Results：After treatment，the total effective rate of clinical effect was 92.65% in the observation group and 79.41% in the control group， the difference being significant(P＜0.05). After two and four weeks of treatment， the average VAS scores in the observation group were 3.22 ± 0.43 and 2.02 ± 0.31 respectively， lower than those of 5.68±0.64 and 4.13±0.75 in the control group，differences being significant(P＜0.05). After four weeks of treatment， the scores of activity of daily living， shoulder joint mobility and muscle strength in Constant- Murley Score in the two groups were increased when compared with those before treatment， and the above three scores in the observation group were higher than those in the control group， differences being significant(P＜0.05). After four weeks of treatment，the values of whole blood low shear viscosity，whole blood high shear viscosity and plasma viscosity in the two groups were decreased when compared with those before treatment，and the above three values in the observation group were lower than those in the control group，differences being significant(P＜0.05). After four weeks of treatment，the levels of TNF-α，COX-2 and IL-1β in the two groups were decreased when compared with those before treatment，and the above three levels of inflammatory factors in serum in the observation group were lower than those in the control group， differences being significant(P＜0.05). After two and four weeks of treatment，the average scores of WHOQOL-BREF were 77.11±6.48 and 92.74±7.35 respectively in the observation group，higher than those of 70.05 ± 6.12 and 80.48 ± 7.59 in the control group， differences being significant(P＜0.05). Conclusion： Chinese medicine hot compress， needle knife and tuina can effectively relieve pain degree in shoulder joint， and improve shoulder joint function， microcirculation status of local blood，activities of daily living and quality of life.