Abstract：Objective：To observe the effect of Zaoren Anshen capsules on sleep quality，quality of life and neurocytokines of patients with depression. Methods：A total of 80 cases of patients with depression were selected and randomly divided into the control group and the observation group，with 40 cases in each group. The control group was treated with paroxetine hydrochloride tablets，and the observation group was additionally treated with Zaoren Anshen capsules based on the treatment of the control group. Both groups were treated for three weeks. Changes in sleep quality，quality of life and neurocytokines before and after treatment in the two groups were observed. The incidence of adverse reactions was compared between the two groups. Results：After treatment，the sleep time in the two groups were prolonged when compared with those before treatment，the time of falling asleep were shortened，and scores of dreaminess， nocturnal awakening， subjective sleep quality and daytime dysfunction were decreased， differences being significant(P＜0.05)；the sleep time in the observation group was longer than that in the control group，the time of falling asleep was shorter，and scores of dreaminess，nocturnal awakening， subjective sleep quality and daytime dysfunction were lower，differences being significant(P＜0.05). After treatment，scores of social function，psychological function，physical function and material life in the two groups were increased when compared with those before treatment(P＜0.05)，and the above four scores in the observation group were higher than those in the control group(P＜0.05). After treatment，levels of brain derived neurotrophic factor(BDNF) and nerve growth factor(NGF) in the two groups were increased when compared with those before treatment(P＜0.05)，and levels of S100B and myelin basic protein(MBP) were decreased(P＜0.05)； levels of BDNF and NGF in the observation group were higher than those in the control group(P＜0.05)， and levels of S100B and MBP were lower(P＜0.05). The incidence of adverse reactions was 32.50% in the observation group，lower than that of 55.00% in the control group(P＜0.05). Conclusion： Zaoren Anshen capsules can improve sleep quality and quality of life in patients with depression，effectively regulate neurocytokines，and reduce the incidence of adverse reactions.