Abstract：Objective：To observe the effect of thunder-fire moxibustion combined with routine therapy on benign prostatic hyperplasia. Methods：A total of 76 cases of patients with benign prostatic hyperplasia of kidney qi deficiency type were randomly divided into the control group and the observation group，with 39 and 37 cases in each group respectively. Both groups were given routine treatment and nursing therapy， and the observation group was additionally treated with thunder- fire moxibustion. Both groups were treated for 30 days. Before and after treatment， complexed prostate- specific antigen(cPSA) in serum， International Prostatic Symptom Score(IPSS)，daily nocturia frequency and quality of life scores in the two groups were compared. Results： After 30 days of treatment， cPSA values in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)； cPSA value in the observation group was lower than that in the control group，the difference being significant(P＜ 0.05). After 10，20 and 30 days of treatment，IPSS and daily nocturia frequency in the observation group were decreased when compared with those before treatment， differences being significant(P＜0.01)； IPSS at three time points in the observation group were lower than those in the control group， and daily nocturia frequency was less，differences being significant(P＜0.01). With the increase of treatment days， the daily nocturia frequency in the two groups was gradually decreased；from the fourth day of treatment， the daily nocturia frequency in the observation group was less than that in the control group. After 16 days of treatment， the daily nocturia frequency in the control group stabilized to more than three times per day. After 29 days of treatment，the daily nocturia frequency in the observation group stabilized to less than two times per day. After 20 and 30 days of treatment，quality of life scores in the observation group were lower than those before treatment， and lower than those in the control group at the same time， differences being significant(P＜0.01). Conclusion：Based on routine intervention measures，the additional application of thunder- fire moxibustion can effectively relieve the clinical symptoms of benign prostatic hyperplasia， improve the prostate function， reduce the number of nocturia and improve the quality of life， with high safety.