Abstract： Objective： To observe the clinical effect of the therapy of modified Xiaoqinglong tang and Sanzi Yangqin tang on cough variant asthma. Methods：A total of 100 children with cough variant asthma were retrospectively selected as the research objects， and divided into the experiment group and the control group according to different treatment methods， with 50 cases in each group. The control group was given montelukast sodium chewable tablets，and the experiment group was given Xiaoqinglong tang and Sanzi yangqin tang based on the treatment of the control group. The Chinese medicine syndrome scores，scores of Leicester Cough Questionnaire(LCQ) and lung function indexes were compared between the two groups before and after treatment，and the clinical effect and incidence of adverse reactions were evaluated. Results： The total effective rate was 96.00% in the experiment group， higher than that of 76.00% in the control group(P＜0.05). After treatment，the Chinese medicine syndrome scores in the two groups were decreased and the LCQ scores were increased when compared with thsose before treatment (P＜0.05)，and the improvement of the above indexes in the experiment group was better than that in the control group(P＜0.05). After treatment，the forced expiratory volume in the first second(FEV1)，percentage of FEV1 in the predicted value(FEV1%)，ratio of FEV1 to forced vital capacity(FEV1/FVC) and peak expiratory flow rate(PEF) in the experiment group were increased when compared with those in the control group(P＜ 0.05)，and the increase in the experiment group was larger than that in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of modified Xiaoqinglong tang combined with Sanzi yangqin tang has a definite curative effect on the treatment of cough variant asthma，which can relieve cough symptoms and improve lung function，with high safety.