Abstract： Objective： To observe the effect of the therapy of compound Haishe capsules combined with memantine hydrochloride tablets on laboratory indexes，cognitive ability and living status of patients with Alzheimer disease(AD). Methods：A total of 80 patients with AD were collected and randomly divided into the control group and the observation group， with 40 cases in each group. The control group was treated with memantine hydrochloride tablets， and the observation group was additionally treated with compound Haishe capsules based on the treatment of the control group. Before and after treatment，the changes of related laboratory indexes， including apolipoprotein A(apoA)， high- density lipoprotein cholesterol(HDL-C)，homocysteine(Hcy)，triglyceride(TG)，apolipoprotein B(apoB) and low-density lipoprotein cholesterol(LDL- C)，were compared between the two groups；before and after treatment，the changes of cognitive ability and living status in the two groups were evaluated by Mini- Mental State Examination (MMSE) and activities of daily living(ADL) respectively，and the clinical effects and adverse reactions were compared between the two groups. Results：After treatment，the levels of apoA，HDL-C and the scores of MMSE，ADL in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of apoB，Hcy，TG，LDL-C were decreased(P＜0.05)；after treatment，the levels of apoA， HDL-C and the scores of MMSE、ADL in the observation group were higher than those in the control group (P＜0.05)， and the levels of apoB， Hcy， TG， LDL- C were lower(P＜0.05). The total effective rate was 95.00% in the observation group，higher than that of 80.00% in the control group(P＜0.05). No medicinerelated adverse reactions occurred in both groups. Conclusion：The therapy of compound Haishe capsules combined with memantine hydrochloride tablets has obvious advantages in the treatment of AD，which can not only improve the related laboratory indexes of patients，but also improve the cognitive ability and living status，without increasing adverse reactions.