Abstract： Objective： To observe the clinical effect of compound Tengli tang combined with chemotherapy for patients after colorectal cancer surgery. Methods：A total of 80 cases of patients who had undergone colorectal cancer surgery were selected and divided into the control group and the observation group according to different treatment methods， with 40 cases in each group. The control group was treated with chemotherapy with FOLFOX6 scheme in four to six weeks after the surgery， and the observation group was additionally given the oral administration of compound Tengli tang based on the treatment of the control group. Chinese medicine syndrome scores， blood routine， tumor markers， physical status，immune function，and inflammatory factor levels were compared between the two groups before and after treatment. Clinical effects， incidence of adverse reactions， recurrence and metastasis status，and one-year and two-year survival status in the two groups were evaluated. Results：The total remission rate was 90.0% in the observation group，higher than that of 60.0% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores，and the levels of blood platelet count(BPC)，red blood cell count(RBC)，white blood cell count(WBC)，carcinoembryonic antigen(CEA)，carbohydrate antigen 199(CA199)，and carbohydrate antigen 724(CA724) in the two groups were decreased when compared with those before treatment(P＜0.05)； Chinese medicine syndrome scores， and levels of CEA， CA199， and CA724 in the observation group were lower than those in the control group，and levels of BPC，RBC and WBC were higher(P＜0.05). Scores of Karnofsky Performance Status(KPS) in the two groups were increased when compared with those before treatment，and the score in the observation group was higher than that in the control group(P＜0.05). After treatment，levels of CD4+ in the two groups were increased when compared with those before treatment，and CD4+ in the observation group was higher than that in the control group(P＜0.05). The recurrence and metastasis rates as well as the incidence of nausea and vomiting， decreased appetite， perioral paralysis， and abdominal distension and diarrhea in the observation group were lower than those in the control group(P＜0.05)，and the one- year and two- year survival rates were higher(P＜0.05). Conclusion： For patients after colorectal cancer surgery， compound Tengli tang combined with chemotherapy has a better effect than that of simple chemotherapy. It can enhance immune function， improve clinical symptoms and reduce the incidence of adverse reactions and recurrence rates.