Abstract：Objective：To observe the clinical effect of Fuzheng Huayu Jiedu prescription on advanced liver cancer and its effect on inflammatory markers and immune function. Methods：A total of 120 cases of advanced liver cancer were randomly divided into the control group and the observation group ， with 60 cases in each group. The control group was treated with routine western medicine transcatheter arterial chemoembolization(TACE)，and the observation group was additionally treated with Fuzheng Huayu Jiedu prescription based on the treatment of the control group. The clinical effects， inflammatory markers and immune function in the two groups were observed. Results： The total effective rate was 53.33% in the observation group，higher than that of 38.33% in the control group(P＜0.05). The control rate was 81.67% in the observation group，higher than that of 61.67% in the control group(P＜0.05). After treatment，the Chinese medicine syndrome scores and levels of interleukin- 6(IL- 6)， interleukin- 10(IL- 10)， tumor necrosis factor- α(TNF- α) and Hypersensitive C- reactive protein(hs- CRP) in the two groups were decreased when compared with those before treatment(P＜0.05)； after treatment， the above score and levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the observation group were increased when compared with those before treatment(P＜0.05)， and the level of CD8 + was decreased(P＜0.05)； there were no significant differences being found in the comparisons of above levels in the control group before and after treatment (P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group(P＜0.05)， and the level of CD8 + in the observation group was lower(P＜ 0.05). The incidence of adverse reactions was 41.67% in the control group，higher than that of 28.33% in the observation group(P＜0.05). Conclusion： The therapy of Fuzheng Huayu Jiedu prescription can effectively improve the clinical effect on advanced liver cancer with less adverse reactions and high safety， and its mechanism may be related to its remarkable reduction of levels of inflammatory factors，inhibition of inflammatory responses，improvement of immune function and enhancement of resistance.