Abstract：Objective：To observe the effect of the therapy of transcutaneous point electrical stimulation and combined spinal- epidural anesthesia on sedation and analgesia in patients during hip replacement. Methods： A total of 80 patients who would receive hip replacement were selected and divided into the control group and the study group according to the random number table method，with 40 cases in each group. The control group was given combined spinal- epidural anesthesia， and the study group was additionally given transcutaneous point electrical stimulation based on the treatment of the control group. Before anesthesia， at the beginning of operation， 30 minutes during operation and after operation， the levels of mean arterial pressure(MAP)， heart rate(HR)， oxygen saturation(SPO2)， bispectral index(BIS)， cortisol(Cor) and catecholamine(CA) in the two groups were recorded respectively. The pain of patients was evaluated by Numeric Rating Scale(NRS) 6 hours，12 hours，24 hours，and 36 hours after operation，and the adverse reactions in the two groups were recorded. Results： Before anesthesia， there were no significant differences being found in the comparisons of levels of MAP，HR，SPO2 and BIS between the two groups(P＞0.05). At the beginning of operation，the levels of MAP and HR in the control group were increased when compared with those before anesthesia(P＜0.05)， and the above two levels in the study group were lower than those in the control group(P＜0.05). The levels of MAP and HR in the control group 30 minutes during operation were increased when compared with those before anesthesia(P＜0.05)； the level of MAP in the study group was increased when compared with that before anesthesia(P＜0.05)，and the level of HR was lower than that in the control group(P＜0.05). After operation，the levels of MAP and HR in the control group were increased when compared with those before anesthesia(P＜0.05)， and the level of MAP in the study group was lower than that in the control group(P＜0.05). At the beginning of the operation，30 minutes during operation，and after the operation，the levels of BIS in the two groups were decreased when compared with those before anesthesia(P＜0.05)，and the levels of BIS in the study group were lower than those in the control group(P＜0.05). At the beginning of operation， there were no significant changes in the levels of Cor and CA in the two groups when compared with those before anesthesia(P＞0.05)； the levels of Cor and CA in the two groups 30 minutes during operation were increased when compared with those before anesthesia(P＜0.05)， and the above two levels in the study group were higher than those in the control group(P＜0.05)； after operation， there were no significant changes in the levels of Cor and CA in the two groups when compared with those before anesthesia(P＞ 0.05). The scores of NRS in the two groups 6 hours，12 hours，24 hours and 36 hours after operation were decreased gradually(P＜0.05)， and the scores of NRS in the study group were lower than those in the control group at the same time respectively(P＜0.05). The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05). Conclusion： The therapy of transcutaneous point electrical stimulation and combined spinal- epidural anesthesia has a good effect on sedation in hip replacement， which can stabilize the levels of MAP and HR， reduce the stress responses， relieve the postoperative pain and reduce the incidence of adverse reactions.