Abstract： Objective： To observe the clinical effect of cervical and lumbar spinal manipulation in the treatment of lumbar disc herniation(LDH)， and the influence on lumbar function， biomechanical characteristics of extensors. Methods： A total of 126 patients with LDH were selected， and divided into treatment group(66 cases) and control group (60 cases) according to different treatment methods. The control group was treated with acupuncture，and the treatment group was treated with cervical and lumbar spinal manipulation on this basis. Clinical effect， TCM syndrome scores， Visual Analogue Scale (VAS) scores， Japanese Orthopaedic Association(JOA) score， biomechanical characteristics of extensors were compared between the two groups. Results：The total effective rate in the treatment group(93.94%) was higher than that in the control group(81.67%) (P＜0.05). After treatment，TCM syndrome scores and VAS scores of the two groups were decreased(P＜0.05)，and the JOA scores were increased(P＜0.05). These indexes in the treatment group were better than those in the control group(P＜0.05). After treatment，the ratios of lumbar flexion and extension in the two groups were decreased when compared with those before treatment(P＜0.05)，and the peak torque，average power in the lumbar extension state were increased(P＜ 0.05)，and the improvement of the above indexes in the treatment group was better than that in the control group(P＜0.05). Conclusion：Cervical and lumbar spinal manipulation is effective in the treatment of LDH， which can reduce pain， improve lumbar function and lumbar balance， and is helpful for the recovery of physiological function and biomechanical characteristics of lumbar extensors.