Abstract： Soreness and heaviness of limbs is the most common clinical symptom of early type 2 diabetes mellitus， which is related to its pathogenesis. Guided by six- channel syndrome differentiation， this paper uses the classic prescriptions to treat patients with early type 2 diabetes mellitus，which has a significant curative effect in improving the symptom of soreness and heaviness of limbs. This paper summarizes its theoretical origins，clinical characteristics and relevant medical cases.