Abstract：Objective：To observe the clinical effect of Shuxuening injection combined with early nursing for stroke patients in rehabilitation period. Methods：A total of 120 cases of stroke patients in rehabilitation period were selected as the study subjects and randomly divided into the observation group and the control group， with 60 cases in each group. Both groups were given clinical routine treatment measures； the control group was additionally given early exercise，and the observation group was additionally treated with Shuxuening injection based on the nursing of the control group. Both groups were treated for one month. Before and after treatment， the scores of modified Rankin Scale(mRS) and Barthel Index(BI) in the two groups were observed and compared. After three- month follow- up， the death status and incidences of sequelae including limb disorder，language disorders，and Poor memory in the two groups were observed and compared. Results： Before treatment， there was no significant difference being found in the comparison of mRS scores and Bl values between the two groups(P＞0.05). After treatment， the mRS scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and Bl values were increased(P＜0.05)；the improvement of the above two indexes in the observation group was more significant than in the control group(P＜0.05). After three-month follow-up，there was no dead case in the two groups； the incidence of sequelae was 6.67% in the observation group and 10.00% in the control group， there being no significance in the difference(P＞0.05). Conclusion： Shuxuening injection combined withearly exercise for stroke patients in rehabilitation period can effectively improve the recovery of neurological function，and enhance their activities of daily living，with low incidence of sequelae.