Abstract： Objective： To observe the clinical effect of Bailing capsulescombined with piperazine ferulate tablets for chronic glomerulonephritis. Methods： A total of 72 cases of patients with chronic glomerulonephritis were divided into the treatment group and the control group according to the random number table method，with 36 cases in each group. The control group was given the oral administration of piperazine ferulate tablets，and the treatment group was additionally treated with Bailing capsules based on the treatment of the control group. Both groups were treated for one month. Chinese medicine syndrome scores，inflammatory factors including interleukin-2(IL-2)，interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) in serum，and the levels of kidney function including serum urea nitrogen，serum creatinine，24- hour urine protein excretion and 1- hour excretion rate of urine red blood cells in the two groups were compared； curative effects and adverse reactions in the two groups were compared. Results： The total effective rate was 97.22% in the treatment group and 80.56% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of IL- 2， IL- 6 and TNF- α in serum between the two groups(P＞0.05). After treatment， the levels of IL- 2 in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of IL- 6 and TNF- α were decreased(P＜0.05)； the improvement of above indexes in the treatment group was more significant than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the score in the treatment group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of serum urea nitrogen，serum creatinine，24-hour urine protein excretion and 1-hour excretion rate of urine red blood cells between the two groups(P＞0.05). After treatment，the above kidney function indexes in the two groups were decreased when compared with those before treatment(P＜0.05)，and the indexes in the treatment group were lower than those in the control group(P＜ 0.05). After treatment，the incidence of adverse reactions was 11.11% in the control group and 8.33% in the treatment group， there being no significance in the difference(P＞0.05). Conclusion： The therapy of Bailing capsules combined with piperazine ferulate tablets for chronic glomerulonephritis has a significant clinical effect，and can effectively reduce systemic inflammatory responses，relieve clinical symptoms and improve kidney function with good safety.