Abstract： Objective： To observe the clinical effect of superfine acupotomy and moxibustion with healing stones on cervical insomnia and its effect on inflammatory factors. Methods：A total of 150 patients with cervical insomnia were selected and divided into the observation group，the control group one and the control group two according to random number table method，with 50 patients in each group. The control group one was treated with estazolam，the control group two was treated with conventional acupuncture， and the observation group was treated with superfine acupotomy and moxibustion with healing stones. Three groups were treated for two courses，two weeks being a course. The sleep quality，pain degree， anxiety degree and levels of serum inflammatory factors before and after treatment as well as the clinical effects were compared among the three groups. Results： The total effective rate was 90.00% in the observation group， 64.00% in the control group one， and 58.00% in the control group two， the total effective rate in the observation group were higher than those in the control group one and control group two (P＜0.017). After treatment，the scores of Pittsburgh Sleep Quality Index(PSQI)，Visual Analog Scale(VAS) and Hamilton Anxiety Scale(HAMA) in the three groups were decreased when compared with those before treatment(P＜0.05)， and the scores of PSQI， VAS and HAMA in the observation group were lower than those in the control group one and the control group two(P＜0.017). After treatment，the levels of serum interleukin- lβ(IL- lβ)， interleukin- 6(IL- 6) and tumor necrosis factor- α(TNF- α) in the three groups were decreased when compared with those before treatment(P＜0.05)，and the levels of serum IL-lβ，IL-6 and TNF-α in the observation group were lower than those in the control group one and the control group two (P＜0.017). Conclusion：Superfine acupotomy and moxibustion with healing stones has a significant effect on the treatment of cervical insomnia，which can improve the sleep quality of patients，relieve the pain and anxiety of cervical spine，and reduce the levels of inflammatory factors.