Abstract：Objective：To observe the effect of Fangji Fuling tang combined with Sini tang on the levels of urinary kidney injury molecule- 1(KIM- 1) and pentraxins 3(PTX3) in patients with sepsis- induced acute kidney injury. Methods： A total of 158 cases of patients with sepsis- induced acute kidney injury were selected and divided into the Sini tang group and the combination group according to the random number table method， with 79 cases in each group. The Sini tang group was treated with Sini tang， and the combination group was treated with Fangji Fuling tang combined with Sini tang. The clinical effects in the two groups were observed； the changes in kidney function indexes including urea nitrogen(BUN)， creatinine(SCr)，uric acid(UA)，neutrophil gelatinase-associated lipocalin(NGAL) levels，KIM-1 and cystatin C(Cys-C)，immune function indexes including NK cell activity，immunoglobulin G(IgG)，immunoglobulin A (IgA) and immunoglobulin M(IgM)，as well as oxidative stress indexes including total antioxidant capacity(TAOC)， superoxide dismutase(SOD)，malondialdehyde(MDA)，PTX3，and angiopioetin 2(Ang2) in the two groups were compared. The changes in Acute Physiology and Chronic Health Evaluation II(APACHE II) scores， Sequential Organ Failure Assessment(SOFA) scores and Chinese medicine syndrome scores before and after treatment in the two groups were compared. Results： After treatment， the levels of BUN， SCr and UA in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)；the levels of BUN，SCr and UA in the combination group were lower than those in the Sini tang group， differences being significant(P＜0.05). After treatment， the levels of KIM-1 and NGAL in the two groups were decreased when compared with those before treatment，and the levels of Cys-C were increased，differences being significant(P＜0.05)；the levels of KIM-1 and NGAL in the combination group were lower than those in the Sini tang group，and the level of Cys-C was higher， differences being significant(P＜0.05). After treatment，the values of NK cell activity，IgG，IgA and IgM in the two groups were increased when compared with those before treatment，and the above four indexes in the combination group were higher than those in the Sini tang group，differences being significant(P＜ 0.05). After treatment，the levels of T- AOC and SOD in the two groups were increased when compared with those before treatment，and MDA levels were decreased，differences being significant(P＜0.05)；the levels of T- AOC and SOD in the combination group were higher than those in the Sini tang group， and MDA level was lower，differences being significant(P＜0.05). After treatment，the levels of PTX3 and Ang2 in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)；the levels of PTX3 and Ang2 in the combination group were lower than those in the Sini tang group，differences being significant(P＜0.05). After treatment，the scores of APACHE II，SOFA and Chinese medicine syndromes in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05)；the scores of APACHE II，SOFA and Chinese medicine syndromes in the combination group were lower than those in the Sini tang group， differences being significant(P＜0.05). After treatment， the total effective rate of clinical effect was 93.67% in the combination group and 82.28% in the Sini tang group， the difference being significant(P＜0.05). Conclusion：The therapy of Fangji Fuling tang combined with Sini tang can significantly improve the clinical symptoms of patients with sepsis- induced acute kidney injury， improve kidney function， reduce the oxidative stress levels of the body，and improve the abnormal expressions of PTX3 and KIM-1.