Abstract： Objective： To observe the clinical effect of the therapy of Longdan Xiegan tang combined with western medicine on herpes zoster. Methods：A total of 120 patients with herpes zoster were divided into the treatment group and the control group according to the random number table method ， with 60 cases in each group. The control group was treated with western medicine，and the treatment group was additionally treated with Longdan Xiegan tang orally based on the treatment of the control group. The clinical effects and adverse reactions were compared between the two groups. The time of controlling herpes， analgesia and incrustation and incidence of postherpetic neuralgia two months after treatment were compared between the two groups. Results：After treatment，the total effective rate was 90.0% in the treatment group and 75.0% in the control group，the difference being significant(P＜0.05). The time of controlling herpes， analgesia and incrustation in the treatment group was shorter than that in the control group， differences being significant(P＜0.05). During follow- up， the incidence of postherpetic neuralgia was 1.7% in the treatment group and 13.3% in the control group，the difference being significant(P＜0.05). During treatment，one case of nausea and one case of diarrhea were found in the treatment group，and one case of nausea was found in the control group，there being no significance in the difference(P＞0.05). Conclusion： The therapy of Longdan Xiegan tang combined with western medicine has a significant curative effect on herpes zoster，shorten the course of disease，and reduce the incidence of postherpetic neuralgia，with high administration safety.