Abstract：Objective：To observe the clinical effect of modified Jichuan jian and Bitong tang for senile functional constipation of spleen- kidney deficiency type. Methods：A total of 142 cases of senile patients with functional constipation of spleen- kidney deficiency type were divided into the observation group and the control group according to the random number table method，with 71 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with modified Jichuan jian and Bitong tang based on the treatment of the control group. Both groups were treated for 60 days. Before and after treatment，the Chinese medicine syndrome scores，serum intestinal neurotransmitters including nitric oxide(NO)， nitric oxide synthase(NOS)， somatostatin(SS)， substance P (SP) and vasoactive intestinal peptide(VIP)， rectal sensory function parameters including first- rectal sensation(FRS)， constant rectal sensation(CRS) and maximum rectal tolerable sensation(MRTS)， and scores of Chinese version of Patient Assessment of Constipation Quality of Life(PAC-QOL) questionnaire in the two groups were compared. The clinical effects and the incidence of adverse reactions in the two groups were evaluated. Results：The total effective rate was 94.37% in the observation group and 83.10% in the control group， the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores， NO， NOS， SS， VIP， FRS， CRS， MRTS， and scores of all dimensions and total scores of PAC- QOL in the two groups were decreased when compared with those before treatment(P＜ 0.05)， SP levels were increased(P＜0.05)， and the improvement in the above indexes in the observation group was better than that in the control group(P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P＞0.05). Conclusion：Modified Jichuan jian and Bitong tang for senile functional constipation of spleen-kidney deficiency type can regulate levels of serum intestinal neurotransmitters， and improve rectal sensitivity and quality of life， with a definite clinical effect.