Abstract： Objective： To observe the clinical effect of Danshen injection combined with pantoprazole sodium for acute pancreatitis and its effect on serum factors. Methods：A total of 98 cases of patients with acute pancreatitis were selected and divided into the observation group and the control group according to the computer grouping method， with 49 cases in each group. The control group was treated with pantoprazole sodium，and the observation group was additionally treated with Danshen injection based on the treatment of the control group. Both groups were treated for 14 days. The changes in Modified CT Severity Index(MCTSI)，Chinese medicine syndrome scores，and serum indexes including tumor necrosis factor- α(TNF- α)，C- reactive protein(CRP) and interleukin- 6(IL- 6) before and after treatment in the two groups were compared. The incidence of complications and survival rates in the two groups were followed up and observed one month after treatment. Results：After treatment，MCTSI scores in the two groups were decreased when compared with those before treatment， and the MCTSI score in the observation group was lower than that in the control group， differences being significant(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the Chinese medicine syndrome score in the observation group was lower than that in the control group，differences being significant(P＜0.05). After treatment，the levels of TNF-α，IL-6 and CRP in the two groups were decreased when compared with those before treatment， and the above three levels in the observation group were lower than those in the control group，differences being significant(P＜ 0.05). After treatment，the incidence of complications was 4.08% in the observation group and 6.12% in the control group，there being no significance in the difference(P＞0.05). The survival rate was 97.96% in the observation group and 95.92% in the control group，there being no significance in the difference(P＞ 0.05). Conclusion：The therapy of Danshen injection combined with pantoprazole sodium for patients with acute pancreatitis has a significant effect，and can effectively improve their clinical symptoms and signs， effectively control the levels of serum inflammatory factors， reduce the incidence of adverse reactions， and increase the survival rate.