Abstract：Objective：To observe the effects of hemodialysis combined with Yishen Huashi granules or Shenshuaining granules on oxidative stress indexes and calcium- phosphorus metabolism in patients with uremia. Methods： A total of 180 cases of patients with uremia were selected as research objects， and were divided into the observation group and the control group according to the random number table method， with 90 cases in each group. The observation group was routinely treated with Yishen Huashi granules combined with hemodialysis， and the control group was routinely treated with Shenshuaining granules combined with hemodialysis. The oxidative stress indexes and calcium- phosphorus metabolism before treatment， one month after treatment and three months after treatment in the two groups were detected and compared. Results：Before treatment，there was no significant difference being found in the comparison of the levels of advanced oxidation protein products(AOPP)， malondialdehyde(MDA)， superoxide dismutase(SOD) and glutathione peroxidase(GSH- Px) between the two groups(P＞0.05). After one-month and three-month treatment respectively，the levels of AOPP and MDA in the two groups were gradually decreased(P＜0.05)，and the levels of SOD and GSH-Px were gradually increased(P＜0.05)；the levels of AOPP and MDA in the observation group were lower than those in the control group at the same time point(P＜0.05)， and the levels of SOD and GSH- Px were higher(P＜0.05). Before treatment， there was no significant difference being found in the comparison of serum phosphorus， serum calcium and calcium- phosphorus product between the two groups(P＞0.05). After one- month and three- month treatment respectively， serum phosphorus and calcium- phosphorus product in the two groups were gradually decreased(P＜0.05)，and the levels of serum calcium were gradually increased(P＜0.05)；serum phosphorus and calcium-phosphorus product in the observation group were lower than those in the control group at the same time point(P＜0.05)，and the levels of serum calcium were higher(P＜0.05). Conclusion： The therapy of hemodialysis combined with Yishen Huashi granules or Shenshuaining granules for patients with uremia can improve their oxidative stress indexes and calcium- phosphorus metabolism， and the therapy of Yishen Huashi granules combined with hemodialysis has a better curative effect.