Abstract：Objective：To observe and study the curative effect and mechanism of the therapy of Yikang Tang combined with warming- needle moxibustion of governor vessel on infertility with polycystic ovary syndrome. Methods： A total of 100 patients were selected and divided into the control group and the observation group， according to different treatment methods， with 50 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Yikang tang orally and warming- needle moxibustion of governor vessel based on the treatment of the control group. The clinical effects were compared between the two groups. Before and after treatment，the Chinese medicine syndrome scores， scores of cervical mucus， endometrial thickness， levels of sex hormones， including estradiol(E2)， luteinizing hormone(LH)， testosterone(T) and follicle stimulating hormone(FSH)， and results of B ultrasound examination， including uterine volume， ovarian volume and number of follicles，were compared between the two groups. Results：After treatment，the total clinical effective rate was 62% in the control group，and was 80% in the observation group，the difference being significant(P＜0.05). After treatment，the Chinese medicine syndrome scores of oligomenorrhea，flooding and spotting，infertility，chest pain and acne in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)； after treatment， the above five Chinese medicine syndrome scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the scores of cervical mucus and endometrial thickness in the two groups were increased when compared with those before treatment， differences being significant(P＜0.05)；the score of cervical mucus and endometrial thickness in the observation group were higher or greater than those in the control group， differences being significant(P＜0.05). After treatment，the levels of E2 in the two groups were increased when compared with those before treatment， and the levels of LH and T were decreased， differences being significant(P＜0.05)， and there was no significant difference being found in the comparison of level of FSH between the two groups before and after treatment(P＞0.05)；after treatment，the levels of E2 in the observation group were higher than those in the control group，and the levels of LH and T in the observation group were lower，differences being significant(P＜0.05)，and there was no significant difference being found in the comparison of level of FSH between the two groups(P＞0.05). After treatment， the uterine volume in the two groups was increased when compared with that before treatment，there being no significant difference(P＞0.05)，and the ovarian volume and number of follicles in the two groups were decreased，differences being significant(P＜0.05)； after treatment， there was no significant difference being found in the comparison of uterine volume between the two groups(P＞0.05)，and the ovarian volume and number of follicles in the observation group were smaller than those in the control group， differences being significant(P＜0.05). Conclusion： The therapy of Yikang tang combined with warming- needle moxibustion of governor vessel can improve the clinical effect on infertility with polycystic ovary syndrome，promote the secretion of cervical mucus，and improve the endometrial thickness and ovarian reserve function，and its mechanism may be related to the regulation of metabolism and endocrine.