Abstract：Objective：To observe the clinical effect of the therapy of Xingqi Sanjie Huayu prescription combined with reduced glutathione on patients who had undergone surgery for primary liver cancer. Methods：A total of 80 patients with primary liver cancer were selected and divided into the control group and the observation group according to the random number table method， with 40 cases in each group. Both groups were treated with laparoscopic hepatectomy. The control group was additionally treated with reduced glutathione orally on the same day after surgery. The observation group was additionally treated with modified Xingqi Sanjie Huayu presription on the same day after surgery based on the treatment of the control group. Before and after treatment， the levels of serum tumor markers， immune function， liver function，Chinese medicine syndrome scores and incidence of adverse reactions were compared between the two groups. Results：After treatment，the levels of alpha-fetoprotein(AFP)，carbohydrate antigen 199 (CA199)， carbohydrate antigen 50(CA50)， interleukin- 12(IL- 12) and tumor necrosis factor- α(TNF- α) in two groups were decreased when compared with those before treatment(P＜0.05)， and the above five levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of IL- 2 in the two groups were increased when compared with those before treatment(P＜0.05)， and the level of IL- 12 in the observation group was higher than that in the control group(P＜0.05). After treatment， the levels of aspartate aminotransferase(AST)， alanine aminotransferase(ALT) and Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the levels of albumin(Alb) were increased(P＜0.05)；the levels of AST，ALT and Chinese medicine syndrome scores in the observation group were lower than those in the control group，and the level of Alb in the observation group was higher(P＜0.05). The incidence of nausea and vomiting， rash， dizziness and abdominal pain in the observation group was lower than that in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Xingqi Sanjie Huayu prescription combined with reduced glutathione for patients who had undergone surgery for primary liver cancer can effectively improve the clinical symptoms， reduce the levels of serum tumor markers， enhance the immune function and liver function，and reduce the incidence of adverse reactions.