Abstract： Objective： To observe the clinical effect of Guanxinning tablets combined with western medicine for coronary heart disease complicated with mild hypertension. Methods：A total of 150 cases of patients with coronary heart disease complicated with mild hypertension were selected and divided into the control group and the observation group according to the random number table method，with 75 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Guanxinning tablets based on the treatment of the control group. The clinical effects in the two groups were compared. Before and after treatment，the changes in frequency and duration of angina pectoris attack， blood pressure， vascular endothelial function indexes including nitric oxide(NO)， thromboxane B2(TXB2) and endothelin- 1(ET- 1)， inflammatory factors including interleukin- 6(IL- 6)， hypersensitive C-reactive protein(hs-CRP) and interleukin-10(IL-10)，and hematocrit(HCT)，whole blood high shear viscosity(BVH) and plasma viscosity(PV) in the two groups were compared. Results： After treatment，the total effective rate of clinical effect was 96.00% in the observation group and 86.67% in the control group， the difference being significant(P＜0.05). After treatment， the frequency and duration of angina pectoris attack in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05). After treatment，frequency and duration of angina pectoris attack in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of systolic blood pressure and diastolic blood pressure in the two groups were decreased when compared with those before treatment，and the above two levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of NO in the two groups were increased when compared with those before treatment，and the levels of TXB2 and ET- 1 were decreased， differences being significant(P＜0.05). After treatment， the level of NO in the observation group was higher than that in the control group，and the levels of TXB2 and ET- 1 were lower，differences being significant(P＜0.05). After treatment，the levels of IL-6 and hs-CRP in the two groups were decreased when compared with those before treatment， and IL- 10 levels were increased，differences being significant(P＜0.05). After treatment，the levels of IL- 6 and hs- CRP in the observation group were lower than those in the control group， and IL- 10 level was higher， differences being significant(P＜0.05). After treatment， the values of BVH， PV and HCT in the two groups were decreased when compared with those before treatment，and the values of the above three indexes in the observation group were lower than those in the control group， differences being significant(P＜0.05). During the treatment， no serious adverse drug reaction occurred in the two groups. Conclusion： The therapy of Guanxinning tablets combined with western medicine for coronary heart disease complicated with mild hypertension has a significant curative effect， which can effectively improve the vascular endothelial function and hemorheology of patients，and relieve systemic inflammatory responses.