Abstract： Objective： To observe the clinical effect of Xingnao Jiedu tang combined with routine treatment for bacterial meningitis and its effect on inflammatory factors. Methods： A total of 96 cases of patients with bacterial meningitis were selected and divided into the observation group and the control group by odd- even number grouping method according to the tail number of cases， 48 cases in each group. The control group was given routine western medicine treatment including ceftriaxone sodium for injection and dexamethasone，and the observation group was additionally treated with Xingnao Jiedu tang based on the treatment of the control group. Clinical effects，changes in the levels of inflammatory factors and incidences of complications in the two groups were observed and compared. Results： The total effective rate was 89.58% in the observation group and 72.92% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of C-reactive protein(CRP)， serum tumor necrosis factor- α(TNF- α) as well as interleukin-6 (IL-6) and interleukin-8(IL-8) in cerebrospinal fluid between the two groups(P＞0.05). After treatment，the levels of CRP， TNF- α， IL- 6 and IL- 8 in the two groups were decreased when compared with those before treatment(P＜0.05)，and all indexes in the observation group were lower than those in the control group(P＜0.05). The incidence of complications was 2.08% in the observation group and 4.17% in the control group， there being no significant difference between the two groups(P＞0.05). Conclusion： The therapy of Xingnao Jiedu tang combined with routine treatment has a significant curative effect in treating bacterial meningitis，which can effectively inhibit inflammatory reactions with fewer complications， and is conducive to rehabilitation of the disease.