Abstract： Objective： To observe the clinical effect of Huoxue Tongluo tang combined with conventional western medicine on sequelae of cerebral infarction． Methods： A total of 82 patients with sequelae of cerebral infarction were selected and divided into the control group and study group by random number table method， with 41 cases in each group． The control group was treated with conventional western medicine， and the study group was treated with self- designed Huoxue Tongluo tang combined with conventional western medicine． The clinical effects， hemorheology indexes， the score of National Institutes of Health Stroke Scale(NIHSS)，the score of Activity of Daily Living(ADL)，levels of inflammatory factors， complication and the incidence of adverse reactions were compared between the two groups ． Results： The total effective rate was 97.6% in the study group and 75.6% in the control group， the difference being significant(P＜0.05)． After treatment， the levels of whole blood high shear viscosity， plasma viscosity，whole blood low shear viscosity and fibrinogen in the study group were lower than those in the control group(P＜0.05)． After treatment， the levels of whole blood high shear viscosity， plasma viscosity， whole blood low shear viscosity and fibrinogen were increased when compared with those before treatment(P＜0.05)， and the above four levels in the study group were lower than those in the control group(P＜0.05)．After treatment，the scores of ADL increased when compared with those before treatment(P＜0.05)， and the scores of NIHSS were decreased(P＜0.05)； the improvement of above two indexs in the study group was significant than that in the control group(P＜0.05)． After treatment， the levels of serum tumor necrosis factor- α(TNF- α)， interleukin- 1β(IL- 1β) and hypersentive C- reactive protein(hs-CRP) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three levels in the study group were lower than those in the control group(P＜0.05)．During the treatment， the incidence of complications was 4.9% in the study group and 26.8% in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 7.3% in the study group and 24.4% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Huoxue Tongluo tang combined with conventional western medicine has a significant effect on the treatment of sequelae of cerebral infarction， which can effectively improve hemorheology indexes and levels of inflammatory factors， enhance the ability of daily living of patients and reduce the degree of neurological impairment，with less complication and adverse reactions.