Abstract： This paper introduces the clinical experience of Professor MA Rong in the treatment of children with epilepsy. Professor MA attached importance to syndrome differentiation in clinical practice and put forward a four- level syndrome differentiation model for children with epilepsy， that is， rough differentiation，fine differentiation，general differentiation and combined differentiation；It is believed that the core pathogenesis of epilepsy is “latent phlegm in the brain collaterals，and qi counterflow and stirring of wind”. The syndrome differentiation and treatment of epilepsy is carried out from the syndrome of phlegm epilepsy， wind epilepsy， blood stasis epilepsy， deficiency epilepsy， etc.， and the basic treatment method of eliminating phlegm to open the orifices and normalizing qi and extinguishing wing. On the basis of syndrome differentiation and prescription，there is a flexible use of insect medicinals such as Zaocys， Pheretima， Scolopendra， Scorpio， and Bombyx Batryticatus， and mineral medicinals such as Frusta Ferri， calcined Magnetitum， Lapis Chloriti， calcined Fluoritum， Gypsum Fibrosum， Talcum， Fossilia Ossis Mastodi，Concha Ostreae，and Succinum，which presents a unique law of medication.