黄芪赤风汤合独活寄生汤加减治疗缺血性脑卒中恢复期临床研究
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R743.3;R277.7

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Clinical Study on Modified Huangqi Chifeng Tang Combined with Duhuo Jisheng Tang for Ischemic Stroke in Convalescence
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    摘要:

    目的:观察黄芪赤风汤合独活寄生汤加减治疗缺血性脑卒中恢复期患者的临床疗效。方法:将102 例缺血性脑卒中恢复期患者按随机数字表法分为联合组和对照组各51 例,对照组接受常规西药治疗,联合组接受黄芪赤风汤合独活寄生汤加减及常规西药治疗。比较2 组临床疗效,比较2 组治疗前后中医证候积分、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)、全血高切黏度、低切黏度、血浆黏度及简化肢体运动功能Fugl-Meyer 评分法(FMA)、日常生活活动能力评定量表(ADL) 评分。结果:联合组临床总有效率92.16%,高于对照组70.59%(P<0.05)。与同组治疗前比较,治疗后2 组各项中医证候积分,TNF-α、IL-6、hs-CRP 水平及全血高切黏度、低切黏度、血浆黏度均降低(P<0.05),FMA、ADL 评分均升高(P<0.05);与对照组治疗后比较,联合组治疗后各项中医证候积分,TNF-α、IL-6、hs-CRP 水平及全血高切黏度、低切黏度、血浆黏度均较低(P<0.05),FMA、ADL 评分均较高(P<0.05)。结论:黄芪赤风汤合独活寄生汤加减治疗缺血性脑卒中恢复期患者可显著提高临床疗效,缓解临床症状,降低血清TNF-α、IL-6、hs-CRP 水平,改善血液流变学指标,对提高患者肢体运动功能和生活自理能力有重要意义。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Huangqi Chifeng tang combined with Duhuo Jisheng tang for ischemic stroke in convalescence. Methods:A total of 102 cases of patients with ischemic stroke in convalescence were divided into the combination group and the control group according to the random number table method, with 51 cases in each group. The control group was treated with routine western medicine, and the combination group was treated with modified Huangqi Chifeng tang combined with Duhuo Jisheng tang and routine western medicine. The clinical effects in the two groups were compared. Before and after treatment,Chinese medicine syndrome scores,tumor necrosis factor-α (TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),whole blood viscosity at high shear rate, whole blood viscosity at low shear rate, blood plasma viscosity, simplified Fugl- Meyer Assessment(FMA) and Activities of Daily Living Scale(ADL) scores in the two groups were compared. Results:The total clinical effective rate was 92.16% in the combination group,higher than that of 70.59% in the control group(P<0.05). After treatment, the Chinese medicine syndrome scores, the levels of TNF- α, IL- 6 and hs- CRP, the whole blood viscosity at high shear rate, whole blood viscosity at low shear rate, and blood plasma viscosity in the two groups were decreased when compared with those before treatment(P<0.05), and the scores of FMA and ADL were increased(P<0.05); the Chinese medicine syndrome scores, the levels of TNF- α, IL-6 and hs-CRP,the whole blood viscosity at high shear rate,whole blood viscosity at low shear rate,and blood plasma viscosity in the combination group were lower than those in the control group(P<0.05), and the scores of FMA and ADL were higher(P< 0.05). Conclusion: Modified Huangqi Chifeng tang combined with Duhuo Jisheng tang for patients with ischemic stroke in convalescence can effectively improve the clinical effect and hemorheology indexes , relieve clinical symptoms and reduce levels of TNF- α, IL-6 and hs-CRP in serum,which is of great significance to improve limb motor function and self-care ability of patients.

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陶晓晓,王琳琳,吴伟林,仇晨峰.黄芪赤风汤合独活寄生汤加减治疗缺血性脑卒中恢复期临床研究[J].新中医,2022,54(19):39-43

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  • 在线发布日期: 2022-10-08
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