Abstract：Objective：To observe the effect of modified Dingxin tang combined with western medicine on oxidative stress，neurotransmitter and cytokines secretion in patients with generalized anxiety disorder with dual deficiency of qi and yin syndrome. Methods： A total of 110 cases of patients with generalized anxiety disorder with dual deficiency of qi and yin syndrome were selected and divided into the control group and the treatment group according to the random number table method，with 55 cases in each group. The control group was treated with routine western medicine，and the treatment group was additionally given the oral administration of modified Dingxin tang based on routine western medicine treatment. The clinical effects and the incidence of adverse reactions in the two groups were observed. The changes in the scores of Chinese medicine syndromes，Hamilton Anxiety Scale(HAMA)，Hamilton Depression Scale(HAMD) and Pittsburgh Sleep Quality Index(PSQI)， the oxidative stress indexes including malondialdehyde(MDA)， reactive oxygen species(ROS)， lipid hydrogen peroxide(LHP) and superoxide dismutase(SOD)， the neurotransmitters including γ-aminobutyric acid(GABA)，glutamate(Glu)，norepinephrine(NE) and dopamine (DA)，the cytokines including C-reactive protein(CRP)，interleukin-6(IL-6) and interleukin-12(IL-12)，as well as the neurotrophic damage factors including neuron- specific enolase(NSE)， acid calcium- binding protein(S- 100β) and glial fibrillary acidic protein(GFAP) before and after treatment in the two groups were compared. Results：The total clinical effective rate was 94.55% in the treatment group and 81.82% in the control group，the difference being significant(P＜0.05). After treatment，the scores of Chinese medicine syndromes including thirst， shortness of breath， poor appetite and pale face in the two groups were decreased when compared with those before treatment，and the above five scores in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the scores of HAMA，HAMD and PSQI in the two groups were decreased when compared with those before treatment， and the scores in treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of MDA， ROS and LHP in the two groups were decreased when compared with those before treatment， and the levels of SOD were increased， differences being significant(P＜0.05). After treatment，the levels of MDA，ROS and LHP in the treatment group were lower than those in the control group，and SOD level was higher，differences being significant (P＜0.05). After treatment， the levels of GABA in the two groups were increased when compared with those before treatment，and the levels of Glu，NE and DA were decreased，differences being significant (P＜0.05)； the level of GABA in the treatment group was higher than that in the control group， and the levels of Glu，NE and DA were lower，differences being significant(P＜0.05). After treatment，the levels of CRP，IL-6 and IL-12 in the two groups were decreased when compared with those before treatment，and the above three levels in the treatment group were lower than those in the control group，differences being significant(P＜0.05). After treatment， the indexes of NSE， S- 100β and GFAP in the two groups were increased when compared with those before treatment， and the above three indexes in the treatment group were higher than those in the control group， differences being significant(P＜0.05). During treatment， no adverse reactions related to the treatment in this study were found. Conclusion： The therapy of modified Dingxin tang combined with western medicine has a good clinical effect in the treatment of generalized anxiety disorder with dual deficiency of qi and yin syndrome， which can reduce oxidative damage， inhibit the expression of serum neurotransmitter， alleviate inflammatory response， protect neurological function，and improve clinical symptoms and psychological state，with high medication safety.