Abstract：Objective：To observe the curative effect of Shenfu injection combined with electroacupuncture for septic shock. Methods：A total of 108 cases of patients with septic shock with sudden collapse of yang qi syndrome were selected as the study subjects， and were assigned into the control group and the treatment group according to the random number table method，with 54 cases in each group. Both groups were given basic treatment of modern medicine for septic shock，and the treatment group was additionally treated with Shenfu injection combined with electroacupuncture. Before treatment and after treatment for 6， 12 and 24 hours， the changes in mean arterial pressure(MAP)， central venous pressure(CVP)， low central venous oxygen saturation(ScVO2)， lactic acid， lactate clearance rate and urine volume in the two groups were compared. Before treatment and after seven-day treatment，the changes in Acute Physiology and Chronic Health Evaluation(APACHEⅡ) scores，Sequential Organ Failure Assessment(SOFA) scores and the number of damaged organs in the two groups were compared. The duration of mechanical ventilation， time of using vasoactive drugs， time of reaching standard of early goal- directed therapy(EGDT)， ICU hospitalization time and 28-day mortality in the two groups were observed. Results：After treatment，the values of MAP，CVP，ScVO2，lactate clearance rate and urine volume at each time point in the two groups were increased when compared with those before treatment， and the values of lactic acid at each time point in the two groups were decreased， differences being significant(P＜0.05)； the values of MAP， CVP，ScVO2，lactate clearance rate and urine volume at each time point in the treatment group were higher than those in the control group， and the value of lactic acid in the control group was lower， differences being significant(P＜0.05). The duration of mechanical ventilation，time of using vasoactive drugs，time of reaching standard of EGDT in the treatment group were shorter than those in the control group，differences being significant(P＜0.05). After seven- day treatment， the APACHE Ⅱ scores， SOFA scores and the number of damaged organs in the two groups were significantly decreased when compared with those before treatment，and the above three indexes in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment， ICU hospitalization time in the treatment group was shorter than that in the control group， the difference being significant(P＜0.05)； the 28- day mortality was 48.15% in the control group and 42.59% in the treatment group，there being no significance in the difference(P＞0.05). Conclusion：Shenfu injection combined with electroacupuncture for septic shock can improve the tissue perfusion and prognosis of patients with septic shock，stabilize the hemodynamics and prevent the deterioration of the disease.