Abstract：Objective：To observe the clinical effect of Qigui Jiangu prescription combined with routine western medicine for osteoporosis of the kidney deficiency and blood stasis type and its effect on bone calcium metabolism and lumbar bone mineral density. Methods： A total of 82 cases of patients with osteoporosis of the kidney deficiency and blood stasis type selected retrospectively and assigned to the observation group and the control group according to different treatment methods，with 40 and 42 cases in each group respectively. The control group was treated with routine western medicine，and the observation group was treated with Qigui Jiangu prescription on the basis of the control group. Bone metabolism， lumbar bone mineral density，Chinese medicine syndrome scores and Visual Analogue Scale(VAS) scores were compared between the two groups before and after treatment；clinical effects and the incidence of adverse reactions were evaluated. Results：The total effective rate was 82.50% in the observation group， higher than that of 61.90% in the control group，the difference being significant(P＜0.05). After treatment，the levels of bone alkaline phosphatase(BALP) and parathyroid hormone(PTH) in the two groups were decreased when compared with those before treatment，and the levels of 25- hydroxyvitamin D3[25- (OH) D3] were increased(P＜0.05)； the levels of BALP and PTH in the observation group were lower than those in the control group， and the level of 25- (OH)D3 was higher(P＜0.05). After treatment， lumbar bone mineral density in the two groups was higher than that before treatment， and VAS scores were lower(P＜0.05)； lumbar bone mineral density in the observation group was higher than that in the control group，and VAS score was lower(P＜0.05). After treatment，Chinese medicine syndrome scores and the total score in the two groups were decreased when compared with those before treatment(P＜0.05)； Chinese medicine syndrome scores and the total score in the observation group were lower than those in the control group， differences being significant(P＜0.05). Conclusion： Qigui Jiangu prescription combined with routine western medicine for osteoporosis of the kidney deficiency and blood stasis type can regulate bone metabolism，effectively improve clinical symptoms and lumbar bone mineral density，and relieve pain.