Abstract：Objective：To observe the clinical effect of acupuncture at Sifeng point(EX-UE10) combined with Xingpi Xiaoshi tang for children with anorexia of spleen failing in transportation type and its effect on Chinese medicine syndrome scores and levels of cytokines in serum. Methods： A total of 72 cases of children with anorexia of spleen failing in transportation type were selected as the study subjects， and divided into the control group and the observation group according to the random number table method， with 36 cases in each group. The control group was treated with Lysine Inosite Vitamin B12 Oral Solution， and the observation group was additionally treated with acupuncture at Sifeng point combined with Xingpi Xiaoshi tang based on the treatment of the control group. Both groups were treated for one month. After one- month treatment，the clinical effects in the two groups were compared. Before treatment and after one- month treatment， the changes in Chinese medicine syndrome scores， growth and development situation and levels of cytokines in serum including gastrin(GAS)，neuropeptide Y(NPY) and Orexin-A in the two groups were compared. Results：After one-month treatment，the total effective rate of clinical effect was 94.44% in the observation group and 77.78% in the control group，the difference being significant(P＜ 0.05). After one- month treatment， the Chinese medicine syndrome scores of abnormal defecation and spontaneous sweating， complexion， food intake and appetite in the two groups were decreased when compared with those before treatment， and the above four scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After one- month treatment， the body mass and height in the two groups were increased when compared with those before treatment，and the symptom scores of food intake were decreased，differences being significant(P＜0.05)；the body mass and height in the observation group were higher than those in the control group，and the symptom score of food intake was lower，differences being significant(P＜0.05). After one- month treatment，the levels of GAS， NPY and Orexin- A in serum in the two groups were increased when compared with those before treatment，and the levels of GAS，NPY and Orexin-A in serum in the observation group were higher than those in the control group，differences being significant(P＜0.05). Conclusion：Acupuncture at Sifeng point combined with Xingpi Xiaoshi tang for children with anorexia of spleen failing in transportation type can effectively relieve clinical symtpoms， improve gastrointestinal tract function and promote the growth and development.