Abstract： Objective： To observe the clinical effect of the therapy of Zhichuan tang combined with theophylline sustained- release tablets on acute exacerbation of bronchial asthma. Methods： A total of 96 patients with acute exacerbation of bronchial asthma were selected and assigned to the control group and the study group according to the random number table method， with 48 cases in each group. Both groups were treated with routine symptomatic treatment. The control group was additionally treated with theophylline sustained- release tablets， and the study group was additionally treated with Zhichuan tang based on the treatment of the control group. Both groups were treated for seven days. The indexes of lung function， levels of immunoglobulin E(IgE) and eosinophils(EOS) count before and after treatment， and clinical effects and disappearance time of clinical symptoms were compared between the two groups. Results：The total effective rate was 95.83% in the study group，higher than that of 83.33% in the control group(P＜0.05). The disappearance time of cough，gasping，expectoration and wheezing rales in the study group were shorter than those in the control group(P＜0.05). After treatment， the forced vital capacity (FVC)，forced expiratory volume in one second(FEV1) and peak expiratory flow(PEF) in the two groups were increased when compared with those before treatment(P＜0.05)，and the FVC，FEV1 and PEF in the study group were higher than those in the control group(P＜0.05). After treatment， the levels of IgE and EOS count in the two groups were decreased when compared with those before treatment(P＜0.05)，and the level of IgE and EOS count in the study group were lower than those in the control group(P＜0.05). Conclusion： The therapy of Zhichuan tang combined with theophylline sustained- release tablets has a definite curative effect on acute exacerbation of bronchial asthma， which can promote the remission of clinical symptoms，improve the lung function，and reduce the airway inflammation.