Abstract：Objective：To observe the clinical effect of modified Zuojin pills combined with mosapril for functional dyspepsia with liver qi invading the stomach syndrome and its effect on gastrointestinal hormones. Methods： A total of 98 cases of patients with functional dyspepsia with liver qi invading the stomach syndrome were divided into the control group and the observation group according to the random number table method，with 49 cases in each group. The control group was treated with mosapril，and the observation group was treated with modified Zuojin pills combined with mosapril. Both groups were treated for eight weeks. The clinical effects，symptom scores，levels of gastrointestinal hormones and incidence of adverse reactions in the two groups were compared. Results：The total effective rate was 95.92% in the observation group， higher than that of 81.63% in the control group(P＜0.05). After treatment， the Functional Dyspepsia Symptom Diary(FDSD) scores and gastrointestinal symptom score(GIS) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the FDSD scores and GIS in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of gastrin(GAS) and motilin(MTL) in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of cholecystokinin(CCK) were decreased(P＜0.05)； the levels of GAS and MTL in the observation group were higher than those in the control group(P＜0.05)，and the CCK level was lower(P＜0.05). The incidence of adverse reactions was 6.12% in the observation group and 10.20% in the control group，and there being no significance in the difference(P＞0.05). Conclusion：Modified Zuojin pills combined with mosapril has a good curative effect in treating functional dyspepsia with liver qi invading the stomach syndrome，can improve symptoms and regulate gastrointestinal hormones，with high safety.