Abstract： Objective： To observe the curative effect of Yishen Qingdu prescription combined with routine therapy on early human immunodeficiency virus(HIV)/acquired immune deficiency syndrome (AIDS)-related kidney damage of spleen-kidney deficiency and internal obstruction of stasis and turbidity type. Methods： A total of 60 patients with early HIV/AIDS- related kidney damage of spleen- kidney deficiency and internal obstruction of stasis and turbidity type were randomly divided into the treatment group and the control group，with 29 and 30 cases completed respectively. Both groups were given highly active anti- retroviral therapy(HAART)，and additionally given with irbesartan tablets timely. The treatment group was additionally treated with Yishen Qingdu prescription. Both groups were treated for 24 weeks. The clinical effects were compared between the two groups. Before and the 24th week of the treatment，the indexes of early kidney damage，including urine protein，urine red blood cell，urinary microalbumin(MA)， urinary β2- microglobulin(β2- MG)， urinary α1- microglobulin(α1- MG)， urinary immunoglobulin(IGU) and urinary albumin- creatinine ratio(ACR)， and safety indexes， including blood routine and liver and kidney function，in the two groups were detected respectively. Results：After 24 weeks of treatment，the total clinical effective rate was 93.10% in the treatment group and 66.67% in the control group，the difference being significant(P＜0.01). The levels of urine protein in the two groups were improved when compared with those before treatment(P＜0.05)， and the improvement in the above level in the treatment group was better than that in the control group(P＜0.05). The levels of urine red blood cell，MA，α1-MG，β2-MG and IGU and ACR were decreased when compared with those before treatment，differences being significant (P＜0.01)，and the above six indexes in the treatment group were lower than those in the control group(P＜ 0.05， P＜0.01). There was no significant difference being found in the comparisons of indexes of blood routine and liver and kidney function in the two groups before and after treatment(P＞0.05)；there was no significant difference being found in the comparisons of above two indexes between the two groups(P＞ 0.05). Conclusion： The therapy of Yishen Qingdu prescription based on routine therapy for patients with early HIV/AIDS-related kidney deficiency of spleen-kidney deficiency and internal obstruction of stasis and turbidity type can effectively lessen the urine protein，reduce the damage of kidney function，and alleviate the clinical symptoms of patients，with a significant curative effect and good safety.