Abstract：Objective：To observe the clinical effect of the therapy of Danshen Chuanxiongqin injection combined with anticoagulant and thrombolysis on deep venous thrombosis(DVT) after lower limb fracture. Methods：A total of 86 cases of patients with DVT after lower limb fracture were divided into the control group and the observation group according to the random number table method， with 43 cases in each group. The control group was treated with anticoagulant and thrombolysis，and the observation group was additionally treated with Danshen Chuanxiongqin injection based on the treatment of the control group. Both groups were treated for two courses，two weeks being a course. The clinical effects after treatment and the coagulation function，including activated partial thromboplastin time(APTT)，plasma prothrombin time (PT) and fibrinogen(Fib)，levels of serum inflammatory factors，including interleukin-1(IL-1)，interleukin-6 (IL- 6) and tumor necrosis factor- α(TNF- α)， and adverse reactions before and after treatment were compared the two groups. Results： The total effective rate was 95.34% in the observation group and 81.39% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparisons of levels of APTT，PT and Fib between the two groups (P＞0.05). After treatment，the levels of APTT and PT were increased when compared with those before treatment(P＜0.05)， the levels of Fib were decreased(P＜0.05)； the levels of APTT and PT in the observation group were obviously higher than those in the control group(P＜0.05)， the level of Fib in the observation was lower(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of IL-1，IL-6 and TNF-α between the two groups(P＞0.05)；after treatment，the levels of IL- 1， IL- 6 and TNF- α in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three levels in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 9.30% in the observation group and 6.97% in the control group， there being no significance in the difference(P＞0.05). Conclusion： The therapy of Danshen Chuanxiongqin injection combined with anticoagulant and thrombolysis has a significant effect on DVT after lower limb fracture，which can improve the coagulation function of patients and reduce the levels of inflammatory factors，with good administration safety.