Abstract：Objective：To observe the clinical effect of the therapy of Xiao'er Feire Kechuan granules on children with bronchiolitis with syndrome of phlegm- heat obstructing the lung. Methods： A total of 62 children with bronchiolitis with syndrome of phlegm- heat obstructing the lung were selected and divided into the treatment group and the control group according to random number table method，with 31 cases in each group. The control group received conventional western medicine treatment measures such as antibacterial，anti-inflammatory and antiasthmatic，and the treatment group was additionally given Xiao'er Feire Kechuan granules orally based on the treatment of the control group. Both groups were treated for one week. The clinical effects， disappearance time of symptoms and signs， and levels of lung function indexes， including tidal volume(TV)， compliance of the respiratory system(Crs) and functional residual capacity(FRC) before and after treatment were compared between the two groups. Results： The total effective rate was 96.77% in the treatment group and 74.19% in the control group，the difference being significant(P＜0.05). After treatment，the disappearance time of cough，panting，wheeze sound and three concave signs in the treatment group was significantly shorter than that in the control group(P＜0.05). Before treatment，there was no significant difference in the levels of TV，Crs and FRC between the two groups(P＞0.05). After treatment， the levels of TV and Crs in the two groups were increased when compared with those before treatment(P＜0.05)， and the FRC levels were decreased(P＜0.05)； the improvement of the above three lung function indexes in the treatment group was better than that in the control group(P＜0.05). Conclusion： The therapy of Xiao'er Feire Kechuan granules for children with bronchiolitis with syndrome of phlegm- heat obstructing the lung can improve the symptoms and signs of children，enhance lung function，and has definite clinical effect.