Abstract：Objective：To observe the clinical effect of the therapy of Qinlian Zhixie tang combined with point application for infantile diarrhea of spleen- stomach dampness- heat type. Methods ： A total of 90 cases of children with diarrhea of spleen-stomach dampness-heat type were selected and divided into the control group and the observation group according to the random number table method，with 45 cases in each group. The control group was treated with point application， and the observation group was additionally treated with Qinlian Zhixie tang based on the treatment of the control group. Both groups were treated for five days continuously. The clinical effects were compared between the two groups. Before and after treatment， the changes of Chinese medicine syndrome scores， immunoglobulin(Ig) and levels of inflammatory factors were compared between the two groups. Results： The total effective rate was 95.56% in the observation group， higher than that of 77.78% in the control group(P＜0.05). After treatment，the scores of primary and secondary symptoms，as well as the levels of serum interleukin- 6 (IL-6)，interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above two scores and three levels in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of serum IgA and IgG in the two groups were increased when compared with those before treatment(P＜ 0.05)，and the above two levels in the observation group were higher than those in the control group(P＜ 0.05). Conclusion：The therapy of Qinlian Zhixie tang combined with point application for infantile diarrhea of spleen- stomach dampness- heat type can effectively relieve the clinical symptoms in children， enhance the immunity，and inhibit the inflammatory responses.