复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症临床研究
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R776.1

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浙江省卫生健康科技计划项目(2022KY1445)


Clinical Study on Fuming Capsules Combined with Polyethylene Glycol Eye Drops for Dry Eye After Cataract Surgery
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    摘要:

    目的:观察复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症的临床疗效。方法:选取80 例白内障术后干眼症患者,以随机数字表法分为对照组和研究组各40 例。对照组给予聚乙二醇滴眼液治疗,研究组在对照组基础上给予复明胶囊治疗,2 组均治疗2 个月。评估2 组临床疗效,比较2 组治疗前后干眼症状评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL) 评分、泪液分泌长度及泪液炎症因子水平。结果:研究组总有效率97.50%,高于对照组82.50%(P<0.05)。治疗后,2 组干涩感、灼烧感、异物感评分及干眼症状总分均较治疗前降低(P<0.05),研究组干涩感、灼烧感、异物感评分及干眼症状总分均低于对照组(P<0.05)。治疗后,2 组BUT、泪液分泌长度均较治疗前延长(P<0.05),FL 评分均较治疗前降低(P<0.05);研究组BUT、泪液分泌长度均长于对照组(P<0.05),FL 评分低于对照组(P<0.05)。治疗后,2 组泪液肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β) 水平均较治疗前降低(P<0.05),研究组泪液TNF-α、IL-1β 水平均低于对照组(P<0.05)。结论:复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症,可有效改善患者的干眼症状,促进其泪液分泌,疗效优于单独使用聚乙二醇滴眼液治疗。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Fuming capsules combined with polyethylene glycol eye drops on dry eye after cataract surgery. Methods:Eighty patients with dry eye after cataract surgery were selected and divided into the control group and the study group according to the random number table method, with 40 cases in each group. The control group was treated with polyethylene glycol eye drops,and the study group was additionally treated with Fuming capsules based on the treatment of the control group. Both groups were treated for two months. The clinical effects in the two groups were evaluated. The dry eye symptoms score,tear film break- up time(BUT),corneal fluorescent staining(FL) score, tear secretion length and tear inflammatory factor level were compared between the two groups before and after treatment. Results:The total effective rate was 97.50% in the study group, higher than that of 82.50% in the control group(P<0.05). After treatment, the scores of dry sensation, burning sensation,foreign body sensation and the total score of dry eye symptoms in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the study group were lower than those in the control group(P<0.05). After treatment,BUT and tear secretion length in both groups were prolonged when compared with those before treatment(P<0.05), and the FL score were decreased when compared with those before treatment(P<0.05); BUT and tear secretion length in the study group were longer than those in the control group(P<0.05),and the FL score was lower than that in the control group(P<0.05). After treatment,the levels of tumor necrosis factor-α(TNF-α) and interleukin- 1β(IL- 1β) in tears of the two groups were decreased when compared with those before treatment(P< 0.05),and the levels of TNF-α and IL-1β in tears of the study group were lower than those of the control group(P<0.05). Conclusion:The therapy of Fuming capsules combined with polyethylene glycol eye drops for dry eye after cataract surgery can effectively improve the symptoms of dry eye and promote the secretion of tears,whose curative effect is better than that of polyethylene glycol eye drops alone.

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倪莉莎,李俊,吴安黛.复明胶囊联合聚乙二醇滴眼液治疗白内障术后干眼症临床研究[J].新中医,2022,54(20):123-126

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  • 在线发布日期: 2022-10-28
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