峻下逐水方隔药脐灸辅助治疗癌性腹水临床研究
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R273;R730.5

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广州中医药大学第一附属医院“创新强院”工程(二期) 科研系列项目(2019HL14)


Clinical Study on Umbilical Moxibustion on Junxia Zhushui Prescription Assisting the Treatment of Malignant Ascites
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    摘要:

    目的:观察峻下逐水方隔药脐灸辅助治疗癌性腹水的效果。方法:将90 例恶性肿瘤伴癌性腹水患者随机分为对照组和试验组,2 组均予癌性腹水的常规治疗与护理方案干预,对照组予安慰剂隔药脐灸,试验组予峻下逐水方隔药脐灸。治疗12 次为1 个疗程,治疗1 个疗程。治疗前后测定腹围、B 超下腹水深度、24 h 出入水量、中医证候积分,检测血常规、肝肾功能等指标,比较2 组治疗后的中医证候改善疗效与腹水改善疗效。结果:治疗1 个疗程后,试验组中医证候改善疗效的总有效率及腹水改善疗效的稳定率均高于对照组,差异均有统计学意义(P<0.01,P<0.05)。试验组腹围值较治疗前减少,差异有统计学意义(P<0.05);2 组治疗后腹围值比较,差异有统计学意义(P<0.05)。对照组在整个治疗周期中,腹水量呈增加趋势,试验组在治疗8 d 后出现排出量明显增多,腹水消退的效果优于对照组。试验组腹痛情况积分、大小便情况积分均较治疗前下降,差异均有统计学意义(P<0.05)。试验组腹痛、精神状态及大、小便情况积分均低于对照组,差异有统计学意义(P<0.05)。2 组各项安全性指标值比较,差异均无统计学意义(P>0.05)。结论:在常规治疗与护理措施的基础上加用峻下逐水方隔药脐灸治疗癌性腹水,可辅助延缓腹水的产生甚至消退腹水,改善患者的腹痛症状,通过大、小便的畅排加快腹水的消退,从而改善患者的精神状态,在短期治疗周期内安全性较好。

    Abstract:

    Abstract: Objective: To observe the effect of umbilical moxibustion on Junxia Zhushui prescription assisting the treatment of malignant ascites. Methods: A total of 90 cases of patients with malignant tumors complicated with malignant ascites were randomly divided into the control group and the experiment group. Both groups were intervened with routine treatment and nursing for malignant ascites;the control group was given umbilical moxibustion on placebo,and the experiment group was treated with umbilical moxibustion on Junxia Zhushui prescription. Both groups were treated for one course, with 12 times of treatment being a course. Before and after treatment, the abdominal circumference, depth of ascites under B ultrasound,24-hour inflow and outflow and Chinese medicine syndrome scores were measured, and the indexes in blood routine and liver and kidney function were detected. After treatment,the curative effects of improvement in Chinese medicine syndromes and ascites in the two groups were compared. Results: After one course of treatment, the total effective rate of improvement in Chinese medicine syndromes and the stability ratio of improvement in ascites in the experiment group were higher than those in the control group, differences being significant(P<0.01, P<0.05). After treatment, The abdominal circumference values in the experiment group was decreased than that in the control group(P<0.05);there was significant difference being found in the comparison of abdominal circumference values between the two groups(P<0.05). During treatment, the ascites volume ascites in the control group showed an increasing trend. After the 8th day of treatment, the discharge in the experiment group was increased significantly,and the effect of ascites disappearance was better than that in the control group. The score of abdominal pain, defecation and urination in the experiment group were decreased when compared with those before treatment, differences being significant(P<0.05). The scores of abdominal pain, mental state,defecation and urination in the experiment group were lower than those in the control group,the difference being significant(P<0.05). There was no significant difference being found in the comparison of the safety test indexes between the two groups(P>0.05). Conclusion:On the basis of routine treatment and nursing measures,the additional treatment of umbilical moxibustion on Junxia Zhushui prescription for malignant ascites can help delay the production of ascites and even reduce ascites,improve the symptoms of abdominal pain,and accelerate the regression of ascites through the smooth discharge of defecation and urination, so as to improve the mental state of patients, with good safety in the short- term treatment period.

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嵇玲瑛,周丽群,曹艳雯,林彩频,李玲,陈勤华,林丽珠.峻下逐水方隔药脐灸辅助治疗癌性腹水临床研究[J].新中医,2022,54(20):171-177

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  • 在线发布日期: 2022-10-28
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