Abstract： Objective： To observe the clinical effect of the therapy of Xuesaitong Granules combined with routine western medicine for acute cerebral infarction(ACI). Methods：A total of 100 cases of patients with ACI were divided into the observation group and the control group according to the random number table method，with 50 cases in each group. Both groups were treated with routine symptomatic treatment of western medicine. The control group was additionally treated with intravenous infusion of Edaravone Injection based on routine treatment，and the observation group was additionally treated with Xuesaitong Granules orally based on the treatment of the control group. Both groups were treated for 14 days. The clinical effects in the two groups was evaluated. Before and after treatment， the Chinese medicine syndrome scores，degree of neurological deficit and laboratory indexes were compared between the two groups. Results：The total effective rate was 92.00% in the observation group，higher than that of 76.00% in the control group(P＜0.05). The Chinese medicine syndrome scores and scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were lower than those before treatment(P＜0.05)；the above two scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of serum tumor necrosis factor- α(TNF- α)， high- sensitivity C- reactive protein(hs- CRP)， homocysteine(Hcy) and neuron- specific enolase(NSE) were lower than those before treatment(P＜0.05)； after treatment，the above four levels in the observation group were lower than those in the control group (P＜0.05). Conclusion： The therapy of Xuesaitong Granules combined with symptomatic treatment of western medicine has a significant curative effect on ACI， which can effectively relieve the clinical symptoms of patients，improve the degree of neurological deficit，alleviate the inflammatory responses of the body，and reduce the levels of Hcy and NSE，so as to control the development of disease.