Abstract：Objective：To observe the clinical effect of the therapy of Dihuang Ziyin Bushen Prescription combined with acupuncture on Parkinson disease with syndrome of liver and kidney insufficiency. Methods：A total of 80 patients with Parkinson disease with syndrome of liver and kidney insufficiency were randomly divided into the observation group and the control group， with 42 and 38 cases in each group respectively. The control group was treated with conventional treatment， and the observation group was additionally treated with Dihuang Ziyin Bushen Prescription combined with acupuncture based on the treatment of the control group. The scores of Unified-Parkinson Disease Rating Scale(UPDRS)，syndrome scores， scores of Parkinson disease quality of life questionnaire(PDQ- 39)， and the levels of superoxide dismutase(SOD)， malondialdehyde(MDA) and interleukin- 1β(IL- 1β) were compared between the two groups before and after treatment. Results： Compared with those before treatment， all dimensions of UPDRS scores in the two groups were decreased after treatment(P＜0.05)； compared with those in the control group after treatment，all dimensions of UPDRS scores in the observation group were low(P＜0.05). After treatment， the syndrome scores and PDQ- 39 scores in the two groups were decreased when compared with those before treatment(P＜0.05). Compared with those in the control group after treatment， the syndrome score and PDQ- 39 score in the observation group were low after treatment(P＜0.05). Compared with those before treatment，the levels of SOD in the two groups were increased(P＜0.05)，and the levels of MDA and IL- 1β were decreased(P＜0.05). Compared with that in the control group after treatment，the level of SOD in the observation group was high(P＜0.05)，and the levels of MDA and IL-1β were low(P＜0.05). The total clinical effective rate was 85.71% in the observation group， significantly higher than that of 57.89% in the control group(P＜0.05). Conclusion：The therapy of Dihuang Ziyin Bushen Prescription combined with acupuncture for patients with Parkinson disease with syndrome of liver and kidney insufficiency can not only effectively relieve the symptoms of syndrome of liver and kidney insufficiency， but also combat oxidative stress and reduce inflammation， which is beneficial to the improvement of the quality of life of patients.