Abstract：Objective：To observe the clinical effect of fumigation- washing sitz bath with Shiyangning Washing Prescription combined with external application of Shidu Ointment for perianal eczema. Methods： A total of 88 cases of patients with perianal eczema were divided into the observation group and the control group according to the random number table method，with 44 cases in each group. The control group was treated with Shidu Ointment ，and the observation group was additionally treated with fumigation-washing sitz bath with Shiyangning Washing Prescription based on the treatment of the control group. The clinical effects in the two groups were evaluated； the scores of clinical symptoms， the quality of life and the recurrence rates in the two groups were compared. Results： The total effective rate was 93.18% in the observation group，higher than that of 77.27% in the control group(P＜0.05). After treatment，the scores of eczema area， skin exudate， pruritus degree and skin lesion in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment，the scores of mental state，physiological function，social relationship and material life in the two groups were increased when compared with those before treatment(P＜0.05)， and each score in the observation group was higher than that in the control group(P＜0.05). The recurrence rate within three months was 6.82% in the observation group，lower than that of 25.00% in the control group(P＜0.05). Conclusion： The therapy of fumigation- washing sitz bath with Shiyangning Washing Prescription combined with external application of Shidu Ointment for perianal eczema has a significant clinical effect， which can effectively improve the clinical symptoms of patients， improve their quality of life，and reduce the recurrence rate.