Abstract： Objective： To observe the clinical effect of buccal acupuncture on moderate- to- severe primary dysmenorrhea. Methods：A total of 80 patients with moderate- to- severe primary dysmenorrhea were selected as the research objects and divided into the observation group and the control group，with 40 cases in each group. Among them， four cases were eliminated and four cases dropped out in the observation group，and two cases were eliminated and four cases dropped out in the control group. A total of 66 cases were eventually involved，with 32 cases in the observation group and 34 cases in the control group. The observation group was treated with buccal acupuncture，and the control group was treated with oral administration of Ibuprofen Sustained-release Capsules. Both groups were treated for three menstrual cycles. The short- term and long- term effects in the two groups were compared. Before and after each course of treatment，the scores of Visual Analogue Scale(VAS)，dysmenorrhea-associated symptoms and Short Form Health Survey 36(SF- 36)， including vitality(VT)， social functioning(SF)， role- emotional(RE)， mental health(MH)， physical functioning(PF)， role- physical(RP)， body pain(BP)， general health(GH) and health transition(HT) were compared between the two groups. Results： After treatment， the scores of VAS in the two groups were decreased when compared with those before treatment，the differences being significant(P＜0.05). After treatment，the scores of dysmenorrhea-associated symptoms in the two groups were decreased when compared with those before treatment，the differences being significant(P＜0.05). After treatment，except PF and VT，the scores of other dimensions in the observation group were better than those in the control group，the differences being significant(P＜0.05). There were significant differences in BP， RE and MH among the three dimensions(P＜0.01). After three cycles of treatment， the total effective rate was 90.63% in the observation group and 85.29% in the control group，the difference being significant(P＜0.05). The total effective rate was 84.38% in the observation group and 70.59% in the control group， the difference being significant(P＜0.05). Conclusion： Buccal acupuncture can effectively relieve moderate- to- severe primary dysmenorrhea， improve the dysmenorrhea- associated symptoms， and improve the quality of life.