Abstract： To introduce the clinical experience of Prof. DANG Zhongqin in treating gastroesophageal reflux disease. Prof. DANG believes that gastroesophageal reflux disease belongs to the category of diseases such as acid regurgitation， gastric cavity pain， plum- stone qi， and esophageal pure heat in Chinese medicine. The disease is located in the esophagus and the stomach and its occurrence of it cannot be separated from the liver and the spleen，whose main pathological factors are fire，heat and stasis，and whose main pathogenesis is the disharmony of the liver and the stomach as well as the ascending counterflow of stomach qi. For its treatment， it is advocated that for fire- heat invasion， if it is excess syndrome，it should be treated by clearing and astringing methods；for imbalance of the middle energizer， if it is deficiency syndrome， it should be treated by harmonizing the center to treat the root； for wood failing to govern free activity， if it is depression syndrome， it should be treated by soothing the liver to regulate qi；and that for long-going blood obstructing collaterals，it should be treated by dissolving stasis to free the collaterals. The prescription is prescribed as Zhenzhu Qingyuan Granules to soothe the liver and break stagnant qi， drain heat and harmonize the center， control acid and relieve pain， and it should be modified according to the symptoms in clinical practice.