麝香保心丸联合宽胸气雾剂治疗冠心病心绞痛临床研究
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R541.4

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Clinical Study on Shexiang Baoxin Pills Combined with Kuanxiong Aerosol for Angina Pectoris Following Coronary Heart Disease
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    摘要:

    目的:观察麝香保心丸联合宽胸气雾剂治疗心绞痛(AP) 的临床疗效。方法:选取114 例AP 患 者,随机分为对照组和观察组各57 例。对照组给予麝香保心丸治疗,观察组在对照组基础上给予宽胸气雾剂 治疗。观察比较2 组临床疗效,治疗前后中医证候积分及心功能指标[射血分数(EF)、心脏指数(CI)、氨 基末端脑钠前体(NT-proBNP)]、心血管事件发生率。结果: 观察组总有效率为96.49%, 对照组为 84.21%, 2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组中医证候积分比较,差异无统计学意 义(P>0.05);治疗后,2 组中医证候积分均较治疗前降低(P<0.05),且观察组中医证候积分低于对照 组(P<0.05)。治疗前,2 组EF、CI、NT-proBNP 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组 EF、CI 水平均较治疗前升高(P<0.05),NT-proBNP 水平较治疗前降低(P<0.05);且观察组上述各项心功 能指标改善较对照组更显著(P<0.05)。治疗期间,观察组无心血管事件发生,对照组心血管事件发生率为 7.02%,2 组比较,差异有统计学意义(P<0.05)。结论:麝香保心丸联合宽胸气雾剂治疗AP 疗效显著,可改 明显善患者的心功能及中医证候,有效预防不良心血管事件。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Shexiang Baoxin Pills combined with Kuanxiong Aerosol for angina pectoris(AP). Methods:A total of 114 cases of AP patients were selected and randomly divided into the control group and the observation group , with 57 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Shexiang Baoxin Pills combined with Kuanxiong Aerosol based on the treatment of the control group. Chinese medicine syndrome scores,cardiac function indexes including ejection fraction(EF),cardiac index (CI),and N-terminal pro-brain natriuretic peptide(NT-proBNP),and the incidence of cardiovascular events before and after treatment,as well as clinical effects,were compared between the two groups. Results: The total effective rate was 96.49% in the observation group and 84.21% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference in the comparison of traditional Chinese medicine(TCM) syndrome scores between the two groups(P>0.05). After treatment, TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05), and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference in the comparison of EF,CI, and NT- proBNP between the two groups(P>0.05). After treatment,EF,and CI in the two groups were increased when compared with those before treatment(P<0.05), and NT- proBNP was decreased(P< 0.05);the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05). During the treatment,there was no cardiovascular event in the observation group, and the incidence of cardiovascular events in the control group was 7.02%,the difference being significant (P<0.05). Conclusion: Shexiang Baoxin Pills combined with Kuanxiong Aerosol has a significant curative effect in treating AP, which can effectively improve cardiac function and Chinese medicine syndromes, and prevent adverse cardiovascular events.

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陈玲才,钱成勇.麝香保心丸联合宽胸气雾剂治疗冠心病心绞痛临床研究[J].新中医,2022,54(24):64-67

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  • 在线发布日期: 2023-01-01
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