Abstract：Objective：To observe the clinical effect of the therapy of Puerarin Injection combined with manual reduction for benign paroxysmal positional dizziness. Methods：A total of 106 patients with benign paroxysmal positional dizziness were selected as the research objects and divided into the control group and the study group according to the random number table method，with 53 cases in each group. The control group was treated with manual reduction， and the study group was treated with Puerarin Injection combined with manual reduction. Before and after treatment， the levels of folic acid， vitamin B12， 25- hydroxyvitamin D[25(OH)D]， estradiol(E2)， total cholesterol(TC)， high- density lipoprotein cholesterol (HDL- C)， low- density lipoprotein cholesterol(LDL- C) and triglyceride(TG) were compared between the two groups. The clinical symptoms in the two groups were evaluated by Vestibular Symptom Index(VSI)， the balance ability by Berg balance scale(BBS)，and quality of life by Dizziness Handicap Inventory(DHI). The clinical effects were compared between the two groups. Results： Before treatment， there was no significant difference being found in the comparisons of levels of E2，folic acid，vitamin B12 and 25(OH)D between the two groups(P＞0.05)；after treatment，the levels of E2，folic acid，vitamin B12 and 25(OH)D in the two groups were increased when compared with those before treatment(P＜0.05)，and the above four levels in the study group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of TC， LDL- C， HDL- C and TG between the two groups(P＞0.05)；after treatment，the levels of TC，LDL- C and TG in the two groups were decreased when compared with those before treatment(P＜0.05)， the levels of HDL- C were increased(P＜0.05)， the levels of TC， LDL- C and TG in the study group were lower than those in the control group(P＜0.05)，and the level of HDL-C in the study group was higher(P＜0.05). Before treatment， there was no significant difference being found in the comparisons of scores of BBS，VSI and DHI between the two groups(P＞0.05)； after treatment， the scores of BBS in the two groups were increased when compared with those before treatment(P＜0.05)，the scores of VSI and DHI were decreased(P＜0.05)，the score of BBS in the study group was higher than that in the control group，and the scores of VSI and DHI in the study group were lower(P＜0.05). The total effective rate was 98.11% in the study group，higher than that of 84.91% in the control group(P＜0.05). Conclusion：Comparing with simple manual reduction，the therapy of Puerarin Injection combined with manual reduction for benign paroxysmal positional dizziness can improve the levels of E2，folic acid，vitamin B12 and 25(OH)D，regulate the blood lipid，relieve the clinical symptoms of patients，improve the balance ability and quality of life of patients，and enhance the clinical effect.