Abstract： Objective： To observe the clinical effect of Tongxinluo Capsules combined with Irbesartan Dispersible Tablets for diabetic nephropathy. Methods： A total of 90 cases of patients with diabetic nephropathy were selected as the study subjects， and randomly divided into the control group and the study group according to the odd-even number method，with 45 cases in each group. Both groups were given basic treatment； the control group was treated with Irbesartan Dispersible Tablets and the study group was treated with Tongxinluo Capsules combined with Irbesartan Dispersible Tablets. Before and after treatment， the changes in kidney function indexes including blood urea nitrogen(BUN)， serum creatinine (SCr) and creatinine clearance rate(CCr)，24-hour urine protein quantification and hemorheology indexes in the two groups were observed. Results：Before treatment，there was no significant difference being found in the comparison of levels of SCr，CCr and BUN between the two groups(P＞0.05). After treatment，the CCr levels in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of SCr and BUN were decreased(P＜0.05)；the improvement of the above indexes in the study group was more significant than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the 24-hour urine protein quantification between the two groups(P＞0.05). After treatment， the 24- hour urine protein quantification in the two groups was decreased when compared with that before treatment(P＜0.05)， and the 24- hour urine protein quantification in the study group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of high shear viscosity，low shear viscosity， plasma viscometry and fibrinogen between the two groups(P＞0.05)， and the above three indexes in the study group were lower than those in the control group(P＜0.05). The levels of low shear viscosity in the two groups were decreased when compared with those before treatment， but only the difference in the study group was significant(P＜0.05). Conclusion： Based on the treatment of the Irbesartan Dispersible Tablets， the additional treatment of Tongxinluo Capsules for diabetic nephropathy can significantly reduce the urine protein of patients，improve kidney function and hemorrheology indexes， and further relieve the injury of the kidney.