Abstract：Objective：To observe the clinical effect of Bushen Jianpi Tang combined with L- carnitine for chronic renal failure(CRF). Methods：A total of 100 cases of CRF patients were randomly divided into the observation group and the control group，with 50 cases in each group. The control group was treated with L- carnitine，and the observation group was treated with L- carnitine combined with Bushen Jianpi Tang. The scores of main symptoms，the indexes of kidney function and the levels of inflammatory factors before and after treatment as well as the clinical effects were compared between the two groups；the incidence of adverse reactions during treatment was recorded. Results：The total clinical effective rate was 86.00% in the observation group，higher than that of 64.00% in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of main symptoms between the two groups(P＞0.05). After treatment，the scores of main symptoms in the two groups were decreased(P＜ 0.05)， and the score in the observation group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of blood urea nitrogen(BUN)，serum creatinine(SCr)，creatinine clearance rate(CCr) and 24- hour urine protein excretion between the two groups(P＞0.05). After treatment， the levels of BUN， SCr and 24- hour urine protein excretion in the two groups were decreased(P＜0.05)， and CCr was increased(P＜0.05)； the levels of BUN， SCr and 24- hour urine protein excretion in the observation group were lower than those in the control group(P＜0.05)， and CCr was higher(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of interleukin- 6(IL- 6)， tumor necrosis factor- α (TNF-α) and high-sensitivity C-reactive protein(hs-CRP) between the two groups(P＞0.05). After treatment， the levels of IL-6，TNF-α and hs-CRP in the two groups were decreased(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05). There was no significant difference being found in the comparison of adverse reactions between the two groups(P＞0.05). Conclusion：The therapy of Bushen Jianpi Tang combined with L-carnitine for CRF patients can significantly enhance the curative effect，improve the main Chinese medicine symptoms，kidney function and microinflammation status and delay the disease progression，with good safety.